Receptor guanylyl cyclase (RGC) family in GtoPdb v.2023.1

The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP). GC-A, GC-B and GC-C expressed predominantly in cardiovascular system, skeletal system intestinal epithelium, respectively. GC-D GC-G found olfactory neuropepithelium Grueneberg ganglion rodents, GC-E GC-F retinal photoreceptors.